Cytoxan and canine anal glan carcinoma

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We are providing curb-side service. Communication with clients and doctors will be largely conducted via phone, Zoom meeting, FaceTime or another platform. Please be patient with the process in order to keep everyone safe. Anal sacs are glands that produce territorial marking secretions which are expelled in small quantities with each bowel movement.
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Identifying and treating anal sac adenocarcinoma in dogs

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Identifying and treating anal sac adenocarcinoma in dogs

Metronomic chemotherapy consists of an anticancer modality treatment. It is applicable in patients at an advanced stage, with the objective of increasing overall survival. The aim of this study was to report an anal sac apocrine carcinoma case in a dog with lymph node metastasis treated with metronomic chemotherapy sequential to surgery and conventional chemotherapy using gemcitabine and carboplatin. Metronomic chemotherapy was associated with cyclooxygenase-2 COX-2 inhibitors, due to strong tumor COX-2 immunohistochemistry expression. Metronomic chemotherapy was initiated with cyclophosphamide, but it was replaced by lomustine, also in metronomic dosage, due to adverse effects. Treatment showed effectiveness, since the patient's overall survival exceeded days 36 months , considerably higher than the mean overall survival expected for this pathology. Canine anal sac apocrine carcinoma is a malignant tumor originated from apocrine glands on the anal sac walls.
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Evaluation of toceranib for treatment of apocrine gland anal sac adenocarcinoma in dogs

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Early detection and aggressive treatment are essential in the successful management of this tumor. Hypercalcemia of malignancy is seen in some cases as a paraneoplastic syndrome and may contribute to presenting clinical signs. Early detection and aggressive treatment are essential in the successful management of this tumor, which emphasizes the importance of a rectal examination as part of a routine physical examination in all animals.
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